探讨脉冲电磁场(PEMFs)治疗绝经后骨质疏松症(PMO)的疗效及最佳治疗频次。比较PMO患者每周一次服用阿仑膦酸钠(共72周,阿仑膦酸钠组)和接受一个疗程PEMFs治疗(共5周,PEMFs组)在不同随访时间骨密度(BMD)、疼痛及平衡功能的改善情况。两组腰椎及全髋骨密度疗效统计量在分组后24周内无统计学差异(P≥0.05),在48周、72周PEMFs组低于阿仑膦酸钠组,差异有统计学意义(P<0.05)。两组视觉模拟评分、时间限制的站起和行走测验以及Berg平衡量表评分的疗效统计量无统计学差异(P>0.05)。与持续服用阿仑膦酸钠相比,一个疗程PEMFs的疗效至少能在24周内维持与阿仑膦酸钠相近,故PEMFs治疗PMO的适宜频次可能为半年一个疗程。 To investigate the efficacy and best treatment frequency of pulsed electromagnetic fields (PEMFs) in the treatment of postmenopausal osteoporosis (PMO). Patients on PMO were treated with alendronate (72 weeks in total, alendronate group) and once-weekly PEMFs (5 weeks in total, PEMFs group) at different follow-up periods for bone mineral density (BMD), pain and Improvement of balance function. There was no significant difference in the therapeutic effect of BMD between lumbar spine and total hip between the two groups (P> 0.05) within 24 weeks and the difference was statistically significant (P> 0.05) at week 48 and week 72 in PEMFs group compared with alendronate group P <0.05). There was no significant difference between the two groups in visual analogue scale, time-limited standing-up and walking test, and Berg Balance Scale score (P> 0.05). The efficacy of one course of PEMFs is similar to that of alendronate at least for 24 weeks compared to continuous alendronate administration, so the appropriate frequency of PEMFs for PMO may be a course of six months.