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作者报道７例，平均年龄７１岁老年人，在围手术期，静脉滴注１．５ｇ头孢唑啉钠的药代动力学改变，得到各项药物动力学参数，并与５例６０岁以下组进行比较，得出老年组在分布相半衰期（ｔ１／２α））、消除相半衰期（ｔ１／２β）均显著延长，亦即在其分布及消除方面均较年轻组减慢（Ｐ＜０．０１）。研究结果表明，对老年人投药要掌握适量、适时、适度的原则。应用头孢唑啉钠１．５ｇ静脉滴注，８ｈ间隔血液谷浓度始终可维持在８μｇ／ｍｌ以上，１２ｈ间隔有近于半数超过８μｇ／ｍｌ，因此，两种用药间隔时间均可选用，但须考虑临床具体患者情况，老年人宜用等间隔投药，药量以每次１．５ｇ为适宜。
The authors report 7 cases, the average age of 71-year-old elderly perioperative intravenous 1.5g cefazolin sodium pharmacokinetic changes, the pharmacokinetic parameters, and 5 cases of patients under 60 years of age (T1 / 2α)), the elimination phase half-life (t1 / 2β) were significantly prolonged, that is, the distribution and elimination of the elderly group were slower than the younger group (P <0.01 ). The results show that, to the elderly to master the appropriate amount of medication, timely and appropriate principles. Application cefazolin sodium 1.5g intravenous infusion, 8h interval blood trough concentration can always be maintained at 8μg / ml above 12h interval more than half of more than 8μg / ml, therefore, the interval between the two drugs can be used, Taking into account the clinical situation of specific patients, the elderly should be administered at equal intervals, the dose to 1.5g for each appropriate.