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抗生素后效应(PAE)系指细菌与抗生素接触,当药物浓度下降,低于MIC或消除后,细菌的生长仍受到持续抑制的效应。随着国内外对PAE的研究日益深入和广泛,目前已发现几乎所有的抗生素都具有PAE。PAE已成为评价抗生素药效动力学的重要参数,并为临床抗生素的合理使用提供了科学依据,对进一步优化抗生素治疗方案具有实际指导意义。1 概述 长期以来,人们都认为抗生素必须达到并维持有效血药浓度才能发挥良好的抗菌效果,忽视了药物对细菌生长繁殖规律的影响及人体免疫机制在杀灭细菌过程中的重要作用。PAE的提出较大程度地完善了药物动力学评价指标,全面反映了药物、细菌及宿主三者的关系。各种抗生
After antibiotic effect (PAE) refers to the contact of bacteria and antibiotics, when the drug concentration drops below the MIC or eliminated, the growth of bacteria are still sustained inhibition of the effect. With the deepening and extensive research on PAE at home and abroad, it has been found that almost all antibiotics have PAE. PAE has become an important parameter to evaluate the pharmacodynamics of antibiotics and provides a scientific basis for the rational use of antibiotics in clinical practice, which has practical guiding significance for further optimization of antibiotic treatment programs. 1 Overview For a long time, people think that antibiotics must reach and maintain effective blood concentration to exert good antibacterial effect, neglecting the influence of drugs on the growth and reproduction of bacteria and the important role of human immune mechanism in killing bacteria. PAE proposed to a greater extent to improve the pharmacokinetic evaluation of indicators, a comprehensive reflection of the drug, bacteria and host the relationship between the three. Various antibiotics