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目的:探讨血液透析滤过加血液灌流对维持性血液透析患者微炎症状态的影响。方法:选择2013年7月至2015年9月来我院进行维持性血液透析患者69例,按随机分配原则分为A、B、C共3组,其中A组28例采用血液透析滤过+血液灌流(HDF+HP)透析方案,B组25例采用普通透析串联血液灌流(HD+HP)透析方案,C组26例采用高通量透析(HF-HD)方案。12周后观察3组治疗前后C反应蛋白(CRP)、血清白细胞介素6(IL-6)的变化情况。结果 :治疗12周后HDF+HP组的CPR、IL-6水平均低于HD+HP、HF-HD组(P<0.05)。结论:血液透析滤过联合血液灌流能明显改善维持性血液透析患者体内的微炎症状态,清除炎症介质效率更优于普通透析联合血液灌流、高通量透析方案。
Objective: To investigate the effect of hemodiafiltration and hemoperfusion on the micro-inflammatory status in maintenance hemodialysis patients. Methods: From July 2013 to September 2015 in our hospital for maintenance hemodialysis in 69 patients, according to the principle of random distribution is divided into A, B, C were 3 groups, of which 28 cases in group A with hemodiafiltration + (HDF + HP) dialysis protocol. 25 patients in group B received HD + HP dialysis and 26 patients in group C received high-flux dialysis (HF-HD). After 12 weeks, the changes of C-reactive protein (CRP) and serum interleukin-6 (IL-6) in 3 groups before and after treatment were observed. Results: After 12 weeks of treatment, the levels of CPR and IL-6 in HDF + HP group were lower than those in HD + HP and HF-HD groups (P <0.05). CONCLUSION: Hemodiafiltration and hemoperfusion can significantly improve the micro-inflammatory status in maintenance hemodialysis patients. The efficiency of clearing inflammatory mediators is better than that of dialysis combined with hemoperfusion and high-flux dialysis.