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目的探讨糖化血红蛋白(HbA1c)和尿微量白蛋白(U-mAlb)联合检测对2型糖尿病肾病早期诊断的临床意义。方法选取100例2型糖尿病患者,依据患者肾功能指标(尿素氮、肌酐、尿酸)正常与否,将其分为非临床DN组(A组)61例、临床DN组(B组)39例,选取健康体检者40例作为对照组,对选取样本进行HbA1c、U-mAlb检测。结果 A、B组U-mAlb、HbA1c指标与对照组相比,差异具有统计学意义(P<0.05),B组U-mAlb、HbA1c指标与A相比,差异具有统计学意义(P<0.05)。结论 HbA1c和U-mAlb两者联合检测对DN的早期诊断、治疗和病情监测具有重要的临床价值。
Objective To investigate the clinical significance of combined detection of glycosylated hemoglobin (HbA1c) and urinary microalbumin (U-mAlb) in the early diagnosis of type 2 diabetic nephropathy. Methods A total of 100 patients with type 2 diabetes mellitus (T2DM) were enrolled in this study. They were divided into non-clinical DN group (group A, 61 cases) and clinical DN group (group B), 39 cases (group B) according to whether they were normal renal function indexes (urea nitrogen, creatinine and uric acid) , Select 40 healthy subjects as a control group, selected samples for HbA1c, U-mAlb detection. Results The difference of U-mAlb and HbA1c between group A and group B was statistically significant (P <0.05). The difference of U-mAlb and HbA1c between group A and group B was statistically significant (P <0.05 ). Conclusion The combined detection of HbA1c and U-mAlb has important clinical value in the early diagnosis, treatment and condition monitoring of DN.