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目的分析环磷酰胺冲击联合激素治疗难治性肾病综合征的临床疗效。方法选取许昌市中心医院2009年8月至2013年3月收治的47例难治性肾病综合征患者,将其随机分为两组,其中对照组26例患者接受常规激素治疗,治疗组21例患者接受环磷酰胺冲击联合激素治疗,对比两组患者临床治疗效果及不良反应。结果两组患者接受治疗后,治疗组治疗总有效率显著优于对照组,差异有统计学意义(P<0.05);治疗组不良反应发生率(4.8%)与对照组(7.7%)比较,差异有统计学意义(P<0.05)。结论采用环磷酰胺冲击联合激素治疗难治性肾病综合征,其临床治疗效果显著,不良反应小,值得在临床中推广使用。
Objective To analyze the clinical effect of cyclophosphamide combined with hormones in the treatment of refractory nephrotic syndrome. Methods 47 patients with refractory nephrotic syndrome admitted from August 2009 to March 2013 in Central Hospital of Xuchang were randomly divided into two groups, 26 patients in the control group received conventional hormone therapy, and 21 patients in the treatment group Patients receiving cyclophosphamide combined with hormone therapy, compared the clinical efficacy and adverse reactions in both groups. Results After treatment, the total effective rate of the treatment group was significantly better than that of the control group (P <0.05). The incidence of adverse reactions in the treatment group (4.8%) was significantly higher than that of the control group (7.7%), The difference was statistically significant (P <0.05). Conclusions The combination of cyclophosphamide and hormones in the treatment of refractory nephrotic syndrome, the clinical treatment of significant effect, small adverse reactions, it is worth promoting in clinical use.