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目的观察探讨阿昔洛韦治疗小儿疱疹性口腔炎的临床效果及其安全性。方法选取我院儿科收治的小儿疱疹性口腔炎患者60例,随机分为治疗组合对照组各30例,两组患儿均采用一般对症处理以及抗感染治疗,对照组加用利巴韦林静脉滴注,治疗组加用阿昔洛韦静脉滴注,每天1次,5d为一个疗程,治疗一个疗程后,观察比较两组患儿的临床疗效及药物的安全性。结果经过治疗后,治疗组总有效率为96.67%,对照组总有效率为76.67%,治疗组在显效率以及总有效率方面均明显优于对照组,以上数据的差异,经过统计学分析,具有统计学意义(P<0.05)。所有60例患儿在用药过程中,没有不良事件的发生。结论应用阿昔洛韦治疗小儿疱疹性口腔炎能够缩短病程,具有良好的临床疗效,且安全性高,值得在临床上推广应用。
Objective To investigate the clinical effect and safety of acyclovir in the treatment of pediatric herpetic stomatitis. Methods A total of 60 pediatric herpetic stomatitis patients treated in our hospital were randomly divided into treatment group and control group, 30 cases each. Both groups were treated with general symptomatic treatment and anti-infective therapy. The control group was treated with ribavirin vein Instillation, acyclovir intravenous drip treatment group, once a day, 5d for a course of treatment, after a course of treatment, the clinical efficacy and drug safety of two groups were observed and compared. Results After treatment, the total effective rate of the treatment group was 96.67%, the total effective rate of the control group was 76.67%, the treatment group was significantly better than the control group in the marked efficiency and total effective rate, the above data differences, after statistical analysis, Statistically significant (P <0.05). All 60 cases of children in the medication process, no adverse events. Conclusion The application of acyclovir in the treatment of pediatric herpetic stomatitis can shorten the course of the disease, has good clinical efficacy, and high safety, which is worth popularizing in clinic.