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目的:探讨胰岛素泵联合连续血糖监测系统(双“C”)强化治疗老年脆性糖尿病临床疗效差异。方法:选取我院2011年1月至2014年10月收治的老年脆性糖尿病患者共120例,采用随机区组法分为对照组(60例)和联合组(60例),分别采用联合胰岛素方案和在此基础上加用双“C”强化辅助治疗。比较2组患者血糖达标率、血糖达标时间、胰岛素用量、治疗前后血糖指标水平及低血糖发生率等。结果:联合组患者血糖达标率明显优于对照组,差异具有统计学意义[97%(58/60)比80%(48/60),P<0.05],血糖达标时间和胰岛素用量均明显优于对照组,差异具有显著意义[(3.46±0.95)d比(6.50±1.82)d,(31.55±4.61)U/d比(40.12±5.94)U/d,P<0.05],治疗后血糖指标水平明显低于对照组、治疗前,差异具有统计学意义[(5.15±0.51)mmol/L比(7.37±0.91)mmol/L,(5.48±1.55)mmol/L比(8.20±2.04)mmol/L,(5.33±1.48)mmol/L比(7.96±2.20)mmol/L,(4.90±1.46)mmol/L比(7.70±2.07)mmol/L,(4.75±1.22)mmol/L比(6.70±1.98)mmol/L,P<0.05]。联合组患者低血糖发生率明显低于对照组,差异具有统计学意义[2%(1/60)比12%(7/60),P<0.05]。结论:双“C”强化辅助联合胰岛素方案治疗老年脆性糖尿病可有效改善血糖控制效果,缩短血糖达标时间,减少胰岛素用量,且有助于降低低血糖发生风险。
Objective: To investigate the clinical efficacy of insulin pump combined with continuous glucose monitoring system (double “C ”) in the treatment of senile brittle diabetes. Methods: A total of 120 elderly patients with fragile diabetes admitted to our hospital from January 2011 to October 2014 were selected and divided into control group (60 cases) and combination group (60 cases) by randomized block method. And on this basis with double “C ” intensive adjuvant therapy. Compare the two groups of patients blood glucose compliance rate, blood glucose compliance time, insulin dosage, before and after treatment, blood glucose levels and the incidence of hypoglycemia. Results: The blood glucose compliance rate in the combined group was significantly better than that in the control group (97% (58/60) vs 80% (48/60), P <0.05], and the blood glucose compliance time and insulin dosage were significantly superior (3.46 ± 0.95) d (6.50 ± 1.82) d, (31.55 ± 4.61) U / d ratio (40.12 ± 5.94) U / d, P <0.05]. After treatment, the blood glucose level (5.15 ± 0.51) mmol / L vs (7.37 ± 0.91) mmol / L, (5.48 ± 1.55) mmol / L vs (8.20 ± 2.04) mmol / L before treatment were significantly lower than those of the control group L, (4.73 ± 1.48) mmol / L, (7.96 ± 2.20) mmol / L, (4.90 ± 1.46) mmol / L vs 7.70 ± 2.07 mmol / L, 1.98) mmol / L, P <0.05]. The incidence of hypoglycemia in the combined group was significantly lower than that in the control group, with a statistically significant difference (2% (1/60) vs 12% (7/60), P <0.05]. CONCLUSION: The double “C” intensive adjuvant combined insulin regimen can effectively improve blood glucose control effect, shorten the time of blood glucose compliance, reduce insulin dosage, and reduce the risk of hypoglycemia.