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目的:观察冠心病患者血浆脂联素(APN)水平,及血浆APN水平与急性冠状动脉综合征(ACS)之间的关系。方法:经冠状动脉造影证实的冠心病患者共110例,其中稳定型心绞痛组35例,不稳定型心绞痛组42组,急性心肌梗死组33例,并且选取20例正常健康人作为对照组。采用ELISA法检测血浆APN水平,同时检测各组生化指标,如空腹血糖、TC、TG、LDL-C、HDL-C等。结果:急性心肌梗死组、不稳定型心绞痛组中血浆APN浓度显著低于稳定型心绞痛以及对照组。logistic多元逐步分析显示吸烟、空腹血糖以及低血浆APN浓度与ACS发生独立相关。结论:血浆APN可能是评估冠心病的新的独立危险因素,可能与ACS的发生有关。
Objective: To investigate the relationship between plasma adiponectin (APN) level, plasma APN level and acute coronary syndrome (ACS) in patients with coronary heart disease. Methods: A total of 110 patients with coronary heart disease confirmed by coronary angiography were enrolled, including 35 patients with stable angina pectoris, 42 patients with unstable angina pectoris and 33 patients with acute myocardial infarction. 20 healthy subjects were selected as control group. Plasma APN levels were measured by ELISA, and biochemical indicators such as fasting blood glucose, TC, TG, LDL-C and HDL-C were detected at the same time. Results: The APN levels in acute myocardial infarction group and unstable angina pectoris group were significantly lower than those in stable angina pectoris group and control group. Logistic multivariate stepwise analysis showed that smoking, fasting plasma glucose, and low plasma APN concentrations were independently associated with ACS. Conclusion: Plasma APN may be a new independent risk factor for coronary heart disease, which may be related to the occurrence of ACS.