采用侧脑室注射胃泌素的方法，以小鼠跑完迷宫所需的时间为指标，观察了胃泌素对小鼠记忆活动的影响。侧脑室注射２ｕｌ含０．２、０．４和０．８ｕｇ胃泌素１ｈ后，小鼠跑迷宫时间及出现的错误次数均高于对照组，且随着胃泌素浓度的增加，小鼠跑迷宫时间相应延长。肌肉注射０．２５ｍｌ含０．４ｕｇ胃泌素１ｈ后，小鼠跑迷宫时间及出现的错误次数与给药前相比没有显著差别。结果提示胃泌素可引起小鼠遗忘，其作用具有中枢特异性。 Using lateral ventricle injection of gastrin method, the time required for mice to run out of the maze as an indicator to observe the gastrin in mice memory activity. Intracerebroventricular injection of 2ul with 0.2,0.4 and 0.8ug of gastrin 1h, the mice maze time and the number of errors occurred were higher than the control group, and with the increase of gastrin concentration, mice Maze time to run accordingly extended. Muscle injection 0.25ml 0.4ug gastrin 1h, the mouse labyrinth maze time and the number of errors compared with before administration there was no significant difference. The results suggest that gastrin can cause mice to forget the role of central specificity.