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目的：了解医院住院患者感染病原菌的分布特点以及耐药情况，为控制医院感染提供依据。方法通过回顾性分析方法，对某医院住院患者送检的标本病原菌检测结果和药敏试验结果进行分析和评估。结果该医院在2年内从住院患者送检的病原学标本中共分离到病原菌4651株，革兰阴性菌构成比为58．53％，革兰阳性球菌构成比为16．66％，真菌构成比为24．81％。在临床分离的病原菌中，多重耐药菌占总菌株数的38．16％；2014年检出多重耐药菌比例占44．86％，明显高于2013年检出的31．73％。临床分离的革兰阴性杆菌耐药率普遍高于革兰阳性球菌，非发酵菌群对碳青霉烯类抗菌药物耐药率均比较高。结论该医院临床分离病原菌中真菌分离率明显增加，多重耐药菌分离率上升，非发酵菌群对碳青霉烯类严重耐药。“,”Objective To investigate the species and drug resistance of pathogens in hospitalized patients so as to provide the basis for the control of the nosocomial infection .Methods Retrospective study was used to analyze and evaluate the re-sults of pathogen detection and antimicrobial susceptibility test of inpatients in the hospital .Result A total of 4 651 strains of pathogens were separated .The gram -negative organisms accounted for 58.53% of isolations, while gram -positive strains for 16.67%and fungus for 24.81%.In the isolates of pathogens ,multi-drug resistant bacteria accounted for 38. 16%of the total isolates.In 2014,the proportion of multi -drug resistant isolates was 44.86%,which was significantly higher than that of 31.73%in 2013.The resistant rate of gram -negative bacteria was higher than that of gram -positive bacteria,and the resistant rate of non -fermentative bacteria to carbapenems was high .Conclusion The isolates rate of fungus is significantly increased ,and non-fermentative bacteria to carbapenems is serious .