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目前,甲状腺的研究有二个主流,一是Basedow病的病因,一是甲状腺激素的代谢及其作用机制。从临床方面来看,有Basedow病患者血中抗TSH(促甲状腺激素)的受体抗体的发现,在甲低病例检测出抗TSH受体抗体以及确立了甲腺激素不应症(Refetoff综合征);其次有游离T_4浓度的放射免疫测定和临床应用、TSH高敏度测定、无痛性甲状腺炎的报告、甲状腺抽取活检、低T_3综合征的临床发现、甲状腺激素代替疗法时血中及乳汁中抗甲状腺剂浓度的测定等。本文仅就抗TSH受体抗体和Refetoff综合征的最新发现概述如下。Ⅰ Basedow病和抗TSH受体抗体很多学者指出,Basedow病的病因与自家免疫机制有关。特别是在Basedow病患者血清中发现有异常
Currently, thyroid research has two main, one is based on the etiology of the disease, one is the thyroid hormone metabolism and its mechanism of action. From a clinical point of view, there is the discovery that anti-TSH (thyroid stimulating hormone) receptor antibodies in the blood of Basedow patients detect anti-TSH receptor antibodies in atypia cases and the establishment of thyroid hormone refractory symptoms (Refetoff Syndrome ); Followed by radioimmunoassay and clinical application of free T_4 concentration, TSH hypersensitivity assay, report of painless thyroiditis, thyroid biopsy, clinical findings of low T 3 syndrome, thyroid hormone replacement therapy in blood and milk Determination of anti-thyroid concentration. The latest findings on anti-TSH receptor antibodies and Refetoff syndrome are summarized below. Ⅰ Basedow disease and anti-TSH receptor antibody Many scholars pointed out that the cause of Basedow disease and its own immune mechanisms. Abnormalities were found in sera of Basedow patients, in particular