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目的评估在重度妊娠高血压患者D二聚体与患者病情严重程度及预后的关系。方法回顾性研究2008年01月至2012年05月ICU患者,纳入其中符合重度妊高症诊断患者60例。测定产前1天D二聚体、APACHEII评分、SOFA评分及肝功能、血小板等其他生化指标。通过比较分析D二聚体与APACHEII评分、器官功能损害的相关性,来评估D二聚体在预测重度妊娠高血压综合征患者病情危重程度及器官功能损害的价值。结果 D二聚体与APACHEII评分有较好的正相关关系(P<0.001r=0.789),D二聚体在MODS组与无MODS组患者中存在统计学差异(P<0.001),相比APACHEII,在妊娠高血压综合症患者中特有的一些病理性变化如肝功能损害,血小板减少,D二聚体也表现出较好的相关性(P<0.001)。结论 D二聚体是判断重症妊高症危重程度的良好指标。
Objective To evaluate the relationship between the severity and prognosis of D-dimer in patients with severe pregnancy-induced hypertension. Methods A retrospective study of 60 patients with ICU diagnosed in our hospital from January 2008 to May 2012 was performed. D-dimer, APACHEII score, SOFA score and liver function, platelet and other biochemical indexes were measured on the first prenatal day. To evaluate the value of D-dimer in predicting the severity of the disease and organ dysfunction in patients with severe pregnancy-induced hypertension by comparative analysis of the correlation between D-dimer and APACHEII score and organ dysfunction. Results There was a positive correlation between D dimer and APACHEII score (P <0.001, r = 0.789). There was a significant difference (P <0.001) between D dimer and MODS patients in comparison with APACHEII , Some of the pathological changes in patients with pregnancy-induced hypertension syndrome such as liver damage, thrombocytopenia, D dimer also showed a good correlation (P <0.001). Conclusion D dimer is a good indicator to judge the severity of severe pregnancy-induced hypertension.