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目的:探讨心理行为干预方法对小细胞肺癌患者化疗影响。方法:对60例小细胞肺癌患者进行心理行为干预临床试验研究。采用WHO疗效评价标准、WHO制定的抗癌药急性及亚急性毒副反应分度标准、中国癌症化疗患者生活质量量表(QLQ-CCC)、卡氏功能状态量表(KPS)、Zung氏抑郁自评量表(SDS)、焦虑自评量表(SAS)测定抑郁、焦虑状况量表作为心理行为干预对小细胞肺癌化疗患者影响的测量指标。在实验设计和患者筛选时对医学变量进行控制,同时对心理变量也进行控制。结果:小细胞肺癌化疗患者经过心理行为干预后,与对照组比较毒副作用明显减少,生活质量明显提高,SDS、SAS评分明显下降,与对照组比较有统计学差异。结论:心理行为干预方法简便实用,可明显减少小细胞肺癌患者化疗毒副反应,改善焦虑、抑郁症状,提高生活质量。
Objective: To investigate the effect of psychological intervention on chemotherapy in patients with small cell lung cancer. Methods: Sixty patients with small cell lung cancer were subjected to psychological and behavioral intervention clinical trials. The standard of WHO curative effect evaluation, acute and subacute toxicity standard of anticancer drugs developed by WHO, QLQ-CCC, KPS, Zung’s depression Self-Rating Scale (SDS), Self-Rating Anxiety Scale (SAS) Depression and Anxiety Scale as a measure of psychological behavior intervention in patients with small cell lung cancer chemotherapy. Control of medical variables during experimental design and patient screening, while also controlling for psychological variables. Results: Compared with the control group, the patients with small cell lung cancer treated with psychological intervention significantly reduced the toxic and side effects, the quality of life improved significantly, and the scores of SDS and SAS decreased significantly compared with the control group. Conclusion: Psychological and behavioral intervention is simple and practical, which can significantly reduce chemotherapy side effects, improve anxiety and depression symptoms and improve quality of life in patients with small cell lung cancer.