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维生素K 具有与血凝系统无直接关系的其他效应。某些维生素K 制剂能加速伤口愈合,刺激结缔组织细胞与细胞间结构生长,促使受损血管抵抗力和渗透性正常化;对胃肠溃疡和实验性肉芽肿溃疡的痊愈也有良好作用。相反,维生素K 拮抗剂则能抑制伤口愈合,引起胃肠溃疡,破坏胶原和弹性纤维,使组织弹性和渗透性发生紊乱。在饮食性维生素K 缺乏时,实验大鼠表现皮肤结缔组织水肿,成纤维细胞分化障碍,胶原和弹性纤维松散。同时,在皮肤切片上,氨基葡聚糖和糖蛋白的组织化学染色发生改变。若给动物注射维生素K 可使结缔组织的上述变化正常化。上述的临床和形态学研究表明,维生素K 对结缔组织有促进合成代谢的作用。
Vitamin K has other effects that are not directly related to the blood clotting system. Certain vitamin K preparations can accelerate wound healing, stimulate the growth of connective tissue cells and intercellular structures, promote the normalization of damaged blood vessel resistance and permeability, and also have a good effect on the healing of gastrointestinal ulcers and experimental granulomatous ulcers. In contrast, vitamin K antagonists can inhibit wound healing, causing gastrointestinal ulcers, destruction of collagen and elastic fibers, tissue elasticity and permeability disorders. In dietary vitamin K deficiency, the experimental rats showed skin connective tissue edema, fibroblast differentiation disorders, loose collagen and elastic fibers. At the same time, the histochemical staining of aminodextran and glycoprotein changed on the skin section. If the animals injected with vitamin K can make the above changes in connective tissue normalization. The above clinical and morphological studies have shown that vitamin K can promote the synthesis of connective tissue metabolism.