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目的探讨硝苯地平联合缬沙坦联合治疗老年性高血压的临床疗效。方法 90例高血压患者随机均分为硝苯地平组、缬沙坦组及联合用药组。随访2年,比较三组的临床疗效及发生心脑血管事件发生情况。结果三组都具有明显降压效果。其中,联合用药组有效率为90%,明显高于缬沙坦组的77%和硝苯地平组的70%(P<0.05);联合用药组发生心脑血管事件1例,另两组各有2例。结论联合应用硝苯地平和缬沙坦,较单独应用这两种药物的降压效果好;但对降低老年高血压患者的心脑血管意外的发病率,无明显优势。
Objective To investigate the clinical efficacy of nifedipine combined with valsartan in the treatment of senile hypertension. Methods 90 patients with hypertension were randomly divided into nifedipine group, valsartan group and combination group. Followed up for 2 years, compared the clinical efficacy of three groups and the occurrence of cardiovascular events. Results all three groups have obvious antihypertensive effect. Among them, the effective rate was 90% in combination group, which was significantly higher than 77% in valsartan group and 70% in nifedipine group (P <0.05); 1 case of cardiovascular and cerebrovascular events occurred in combination group, In 2 cases. Conclusions Combination of nifedipine and valsartan has a better antihypertensive effect than the combination of these two drugs alone. However, there is no obvious advantage in reducing the incidence of cardiovascular and cerebrovascular accidents in elderly hypertensive patients.