吡醇羟乙脂引起的草酸钙结石:一种新的药物引起的代谢性肾结石

来源 :国外医学.泌尿系统分册 | 被引量 : 0次 | 上传用户:hengheng5251984
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吡醇羟乙脂(Piridoxilate)是一种乙醛酸和Vit B_6的复合物,用于治疗冠心病,每片含吡醇羟乙脂150mg,长效硝酸甘油50mg。乙醛酸盐降低肌细胞的耗氧量,加Vit B_6是防止乙醛酸盐转化为终术产物草酸盐过多,Vit B_6为乙醛酸盐转化为甘氨酸。吡醇羟乙脂引起肾结石认识时间不长。作者在1982—1985年间发现长期用吡醇羟乙脂后产生草酸钙结石27例。自动排出及手术取出的结石作形态学和结构分析。结果如下: Piridoxilate is a complex of glyoxylate and Vit B_6 for the treatment of coronary heart disease, each containing 150 mg of pirnoazein and 50 mg of long-acting nitroglycerin. Glyoxylate reduced muscle cell oxygen consumption, plus Vit B_6 is to prevent conversion of glyoxylate to the end product of oxalate too much, Vit B_6 glyoxylate into glycine. Pyridoxine caused kidney stones do not know time. In 1982-1985, the authors found 27 cases of calcium oxalate stones after long-term use of piraolone. Automatic discharge and surgical removal of stones for morphological and structural analysis. The result is as follows:
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