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越来越多的研究表明,从雌性哺乳动物和人卵巢表面上皮细胞中能够分离出少量端粒酶活性高、表达干性标志且能被诱导发育成为卵母细胞样的卵巢干细胞,即生殖干细胞(GSCs)。体内移植后,可使不孕小鼠产生排卵,生育后代。GSCs可能在维持出生后卵泡的再生与修复中发挥重要作用。然而,GSCs的研究还存在一些缺陷和存在性的直接证据。本文主要对卵巢GSCs的研究进展和潜在的应用前景进行了综述。
An increasing number of studies have shown that a small amount of telomerase activity can be isolated from female mammalian and human ovarian surface epithelial cells and express dry markers and can be induced to develop into oocyte-like ovarian stem cells, ie, germline stem cells (GSCs). In vivo transplantation, can make infertility mice ovulation, fertility offspring. GSCs may play an important role in the maintenance of follicular regeneration and repair after birth. However, GSCs’ research still has some direct evidence of defects and existence. This article mainly reviews the research progress of ovarian GSCs and their potential application prospects.