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目的探讨冠心病伴中、重度牙周炎患者牙周基础治疗后,牙周状况及血清白介素-1β(IL-1β)和肿瘤坏死因子α(TNF-α)水平的变化。方法选择100名伴有中、重度牙周炎的冠心病患者,随机分为两组,研究组50例患者在心内科治疗基础上行牙周基础治疗,对照组50例患者仅行心内科治疗。观察各组治疗前、治疗8周后的牙周临床指标(龈沟出血指数、探诊深度、临床附着丧失)和血清IL-1β、TNF-α水平。结果牙周基础治疗后,研究组的各项牙周临床指标均有好转,血清中IL-1β及TNF-α水平明显降低,差异有统计学意义(P<0.01)。研究者与对照组相比,治疗前的各项指标差异无统计学意义,治疗8周后,研究组的牙周临床指标和血清IL-1β、TNF-α水平与对照组相比均有明显差异,有统计学意义(P<0.01)。结论牙周基础治疗不仅能改善牙周状况,还可降低血清IL-1β和TNF-α和水平,有利于冠心病的预防和治疗。
Objective To investigate the changes of periodontal status, serum levels of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in patients with coronary heart disease complicated with moderate and severe periodontitis after periodontal basic treatment. Methods A total of 100 coronary heart disease patients with moderate and severe periodontitis were selected and randomly divided into two groups. 50 patients in the study group underwent basic periodontal treatment on the basis of cardiology and 50 patients in the control group received only cardiology. Periodontal parameters (gingival sulcus bleeding index, probing depth, clinical attachment loss) and serum levels of IL-1β and TNF-α before and 8 weeks after treatment were observed in each group. Results After periodontal basic treatment, the clinical periodontal indexes of the study group all improved, and the levels of IL-1β and TNF-α in the serum decreased significantly. The difference was statistically significant (P <0.01). Compared with the control group, there was no significant difference in each index between the two groups before and after treatment. After 8 weeks of treatment, the clinical parameters of the periodontal group, serum IL-1β and TNF-α in the study group were significantly higher than those in the control group The difference was statistically significant (P <0.01). Conclusion The basic periodontal treatment can not only improve the periodontal status, but also decrease the level of serum IL-1β and TNF-α, which is propitious to the prevention and treatment of coronary heart disease.