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目的:检测口腔鳞癌中环氧合酶-2(COX-2)和微淋巴管密度(MLVD)的表达,探讨COX-2与口腔鳞癌淋巴管生成的关系及临床意义。方法:应用免疫组织化学染色(S-P法)检测40例口腔鳞癌组织、14例正常口腔黏膜组织中COX-2的表达情况。应用免疫双重组织化学染色检测肿瘤中的MLVD。结果:COX-2在口腔鳞癌中的阳性表达率为70.0%,明显高于对照组(P<0.01)。COX-2的表达与口腔鳞癌颈淋巴结转移、TNM分期相关(P<0.05)。COX-2表达阳性组的MLVD值为23.3±1.9,显著高于阴性组的MLVD值16.9±2.2(t=9.295,P<0.01)。结论:COX-2在口腔鳞癌组织中表达明显上调,并与淋巴管生成、颈淋巴结转移及TNM分期等临床病理生物学行为有关,COX-2可能在口腔鳞癌的生长及转移中起重要作用。
Objective: To investigate the expression of cyclooxygenase-2 (COX-2) and lymphatic vessel density (MLVD) in oral squamous cell carcinoma and to investigate the relationship between COX-2 and lymphangiogenesis in oral squamous cell carcinoma and its clinical significance. Methods: The expression of COX-2 in 40 cases of oral squamous cell carcinoma and 14 cases of normal oral mucosa was detected by immunohistochemical staining (S-P method). Immunohistochemical staining for MLVD in tumors was performed. Results: The positive expression rate of COX-2 in oral squamous cell carcinoma was 70.0%, which was significantly higher than that in the control group (P <0.01). The expression of COX-2 was correlated with cervical lymph node metastasis and TNM staging in oral squamous cell carcinoma (P <0.05). The MLVD value of COX-2 positive group was 23.3 ± 1.9, which was significantly higher than that of negative group (16.9 ± 2.2, t = 9.295, P <0.01). CONCLUSION: The expression of COX-2 in oral squamous cell carcinoma is significantly up-regulated, and is related to clinicopathological and biological behaviors such as lymphangiogenesis, cervical lymph node metastasis and TNM staging. COX-2 may play an important role in the growth and metastasis of oral squamous cell carcinoma effect.