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目的探讨大豆异黄酮对口腔白斑癌变的防治作用。方法将60只雄性金黄地鼠随机分为4组,前6周(每周3次)在A、B组动物颊囊涂DMBA溶液,C组涂丙酮,D组正常饲养。接下来12周,每天给B组动物灌喂大豆异黄酮溶液,A、C组灌生理盐水。实验结束时处死动物,收集标本。结果与A组相比,B组肿瘤出现的平均时间稍晚,分别是(12·50±2·22)周和(13·30±1·49)周,其差异无统计学意义(P=0·30)。A组和B组相比,肿瘤的潜伏期和发生率差异均无统计学意义。结论在金黄地鼠颊囊黏膜癌模型中未发现大豆异黄酮对白斑癌变具有防治作用。
Objective To investigate the preventive and therapeutic effects of soy isoflavones on oral leukoplakia. Methods Sixty male golden hamsters were randomly divided into four groups. Animals in group A and group B received DMBA solution in the first 6 weeks (3 times a week), group C received acetone, and group D was reared normally. In the next 12 weeks, the animals in Group B were fed with soy isoflavone solution daily, while Group A and C were given saline. Animals were sacrificed at the end of the experiment and samples were collected. Results Compared with group A, the mean time of tumor appearance in group B was slightly later (12 · 50 ± 2.22 weeks and 13 · 30 ± 1 · 49 weeks, respectively, with no significant difference (P = 0 · 30). There was no significant difference in the latency and incidence of tumor between group A and group B. Conclusion In the hamster cheek pouch mucosa cancer model did not find soy isoflavones on the prevention and treatment of leukoplakia.