肺癌晚期约 5 0 %患者并发胸腔积液 ,且胸腔积液生长迅速 ,一般化疗效果欠佳 ,我们应用羟基喜树碱及羟基喜树碱加凝血酶胸腔内注入治疗 ,疗效较好 ,现将结果报道如下。1　资料与方法1.1　病例选择　癌性胸积液者 40例 ,其中男 16例 ,女 2 4例 ,年龄 3 5～ 78岁。随机分成两组 , About 50% of patients with advanced lung cancer complicated with pleural effusion, and pleural effusion rapid growth, the general effect of chemotherapy is not good, we use hydroxycamptothecin and hydroxycamptothecin plus thrombin intrathoracic injection therapy, the effect is better, now The results are reported below. 1 Materials and Methods 1.1 Case Selection Forty cases of cancerous fluid, including 16 males and 24 females, aged 35 to 78 years. Randomly divided into two groups,