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目的 :探讨FK 50 6抑制角膜缘干细胞移植术后免疫排斥反应的临床可行性与有效性。方法 :应用前瞻性评估研究方法 ,将角膜缘移植术后病例 64只眼按随机原则分投药组及对照组各半 ,投药组应用 0 5%FK 50 6滴眼液 ,对照组应用 1 %CsA滴眼液。平均随访期半年 ,以术后角膜缘植片新生血管、水肿、混浊及溶解程度为临床主要评估指标。结果 :随访期内在新生血管指数、上皮排斥发生率、移植排斥指数及假性胬肉指数四项指标投药组低于对照组 ,其差异具有显著性。结论 :角膜缘移植术后局部应用FK 50 6可有效抑制移植片免疫排斥反应的发生。
Objective: To investigate the clinical feasibility and effectiveness of FK 50 6 in inhibiting immune rejection after limbal stem cell transplantation. Methods: According to the prospective evaluation method, 64 eyes of limbal transplantation patients were randomly divided into two groups according to randomization principle: 0 5% FK 50 6 eye drops and 1% CsA Eye drops. The average follow-up period of six months, postoperative corneal limbal neovascularization, edema, turbidity and the degree of dissolution as the main clinical evaluation indicators. Results: During the follow-up period, the indexes of angiogenesis index, epithelial rejection rate, graft rejection index and pseudo-meat index were lower than those of the control group, and the difference was significant. CONCLUSION: Topical application of FK 50 6 after limbal transplantation can effectively suppress the occurrence of graft rejection.