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目的观察益气健脾法治疗儿童脾虚型功能性消化不良(FD)的疗效及对血清胃动素(MTL)、神经肽(NPY)、5-羟色胺(5-HT)的影响。方法将160例FD患儿随机分为治疗组和对照组,各80例。对照组给予吗丁啉糖浆口服,治疗组给予中药口服,连续治疗3月后观察2组的临床疗效及血清MTL,NPY,5-HT水平的变化。结果治疗组总有效率为88.75%,对照组为66.25%,2组总有效率比较,差异有统计意义(P<0.05)。治疗前2组MTL,NPY,5-HT水平比较,差异均无统计意义(P>0.05);治疗后2组MTL,NPY均明显上升(P<0.05),5-HT明显下降(P<0.05),组间比较,治疗组上升与下降幅度更大(P<0.05)。结论益气健脾法治疗儿童脾虚型FD疗效显著,其作用机制可能与调节MTL,NPY,5-HT水平有关。
Objective To observe the curative effect of Yiqi Jianpi Decoction on children with functional dyspepsia (FD) and its effect on serum motilin, neuropeptide (NPY) and 5-hydroxytryptamine (5-HT). Methods 160 cases of FD children were randomly divided into treatment group and control group, each 80 cases. The control group was given morphine syrup orally, and the treatment group was orally administered with Chinese herbs. After three months of continuous treatment, the clinical curative effect and the changes of serum MTL, NPY and 5-HT levels were observed. Results The total effective rate was 88.75% in the treatment group and 66.25% in the control group. The total effective rate in the two groups was statistically significant (P <0.05). There was no significant difference in the levels of MTL, NPY and 5-HT between the two groups before treatment (P> 0.05). MTL and NPY increased significantly (P <0.05) and 5-HT decreased ), The treatment group increased and decreased more significantly (P <0.05). Conclusion The method of benefiting qi and invigorating the spleen to treat children with spleen deficiency syndrome has a significant curative effect, which may be related to the regulation of MTL, NPY and 5-HT.