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我们观察了腹腔注射三尖杉酯碱对大鼠移植性肝癌(BERH-2)和皮下注射全蝎提取物与LRH.A对乳腺癌组织腺苷酸环化酶(AC)和环腺苷酸磷酸二酯酶(PDE)比活力的影响。发现:1.三尖杉酯碱能使肝癌组织AC比活力升高28.0％,PDE比活力降低48.1％(P<0.002),AC/PD正比值增加144.4％(P<0.005);对正常肝则无明显作用。2.全蝎提取物和LRH-A抑制乳腺癌生长,并能使乳腺癌组织中AC比活力在停药第一天降低,而PDE比活力不变,AC/PDE比值减小。在停药第八天,乳腺癌组织AC比活力升高,PDE比活力降低,AC/PD正比值增大。结果表明抗癌药物通过改变AC与PDE活力,使cAMP水平过高或过低,抑制肿瘤生长。
We observed intraperitoneal injection of harringtonine for rat transplanted liver cancer (BERH-2) and subcutaneous injection of whole wolfberry extract with LRH.A for breast cancer tissue adenylate cyclase (AC) and cyclic adenylate The effect of phosphodiesterase (PDE) specific activity. Findings:1. harringtonine can increase the specific activity of liver cancer by 28.0%, the specific activity of PDE by 48.1% (P<0.002), the positive ratio of AC/PD by 144.4% (P<0.005); There is no obvious effect. Whole wolfberry extract and LRH-A inhibited the growth of breast cancer, and could decrease the specific activity of AC in breast cancer tissue on the first day of discontinuation, while the specific activity of PDE did not change and the ratio of AC/PDE decreased. On the eighth day of discontinuation, the specific activity of AC increased, the specific activity of PDE decreased, and the positive ratio of AC/PD increased. The results showed that the anti-cancer drugs can inhibit the tumor growth by changing the AC and PDE activity and making the cAMP level too high or too low.