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栓剂是比较古老剂型之一。作为直肠给药既可产生局部作用,也可产生全身作用,以代替口服或注射给药。所以,栓剂剂型目前仍为制剂、临床各方面所重视。作为栓剂的基质,一向认为柯柯豆脂是较理想的。但世界上只有少数国家有生产,所以30多年来国内外都在研究柯柯豆脂的代用名。在国内曾对乌桕脂、猴香子油、香果脂等的理化性质、对粘膜的刺激性、药剂学实验等进行了研究。结果认为:乌桕脂的熔点较高,且因产地不同而异,目前南方有
Suppositories are one of the more ancient dosage forms. As a rectal administration may have a local effect, but also produce systemic effects, instead of oral or injection administration. Therefore, the suppository dosage form is still the preparation, all aspects of clinical attention. As a suppository matrix, it has always been considered that Coke soy butter is more desirable. However, only a few countries in the world have production, so more than 30 years at home and abroad are studying the alternative name of Ke Ke soybean fat. In the country had Wuhu fat, monkshood oil, fragrant fruit and other physical and chemical properties, the mucosal irritation, pharmaceutical experiments were studied. The results showed that: the highest melting point of tallow fat, and vary according to the origin, the South has