评价了重瓣曼陀罗(Datura fastuosa)中一种醉茄内酯成分醉茄内酯D的抗应激活性。方法:将雄性大鼠(150～200g)分为四组,每组6只。两个对照组:一组空白对照,另一组每日口服丙二醇-水(1:1)1ml;另外两组,分别每日口服醉茄内酯D(20mg/kg)和地西泮(1mg/kg)的水丙二醇溶液,连续6日。在第4天给药1h后,采用开阔法试验,将大鼠放入暗室内的开阔装置中5min,评价药物对大鼠探究行为的影响。观察指标:①记录动物穿行的格数作为移动指标 The anti-stress activity of esculetolactone D, an inulinatolide from Datura fastuosa, was evaluated. Methods: Male rats (150-200 g) were divided into four groups of 6 rats each. Two control groups: one blank control group, the other oral propanediol-water (1:1), 1 ml daily; the other two groups, oral gheegolide D (20 mg/kg) and diazepam (1 mg) /kg) Water propylene glycol solution for 6 consecutive days. One hour after the administration on the 4th day, the open method test was used to place the rats in an open room in a dark room for 5 minutes to evaluate the effect of the drug on the rat’s exploratory behavior. Observation indicators: 1 record the number of animals walking as a mobile index