目的探讨儿科无痛胃镜检查时联合应用异丙酚和芬太尼的安全性。方法对112例患儿在胃镜检查时联合应用异丙酚和芬太尼麻醉,重点观察检查过程中患儿的术前、中、后BP、HR、RR、SaO2的变化。结果检查中有23例(占20.5%)出现收缩压/舒张压、呼吸频率下降,与检查前比较,P<0.05,但均为一过性,检查结束后很快恢复正常。检查前、中、后HR、SaO2均无明显变化。结论异丙酚联合芬太尼应用于胃镜检查具镇静效果好、安全性高、呼吸循环功能影响小、完全清醒时间短、无后遗症等优点,值得临床推广应用。 Objective To investigate the safety of propofol and fentanyl in pediatric painless gastroscopy. Methods A total of 112 children undergoing gastroscopy were anesthetized with propofol and fentanyl. The changes of BP, HR, RR and SaO2 were observed before, during and after the operation. RESULTS: Twenty-three patients (20.5%) had systolic / diastolic pressure and decreased respiratory rate. Compared with those before the test, P <0.05, all of them were transient and returned to normal soon after the test. Check before, during, after HR, SaO2 no significant change. Conclusion Propofol combined with fentanyl used in gastroscopy with good sedation, high safety, little effect of respiratory function, complete recovery time is short, no sequelae and other merits, worthy of clinical application.