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目的:探讨冰香散挥发油对甲Ⅰ型流感病毒的抑制作用。方法:采用鸡红细胞凝集实验以及MTT法观察其挥发油成分在体外对甲Ⅰ型流感病毒的预防、直接抑制和治疗作用。结果:冰香散挥发油仅对甲I型流感病毒有预防和直接抑制作用,其治疗作用不明显。利用MTT法测得在预防作用中的半数抑制浓度为5.89μg/mL,对应的治疗指数为3.28;对病毒直接抑制作用中的半数抑制浓度为9.56μg/mL,对应的治疗指数为2.02。结论:冰香散挥发油体外对甲Ⅰ型流感病毒FM1有预防作用和直接抑制作用。
Objective: To investigate the inhibitory effect of Bingxian San volatile oil on influenza type A virus. Methods: The chicken erythrocyte agglutination test and MTT method were used to observe the prevention, direct inhibition and therapeutic effect of volatile oil components on influenza A virus in vitro. Results: Essential Oil of Bingxian Powder had preventive and direct inhibitory effects on influenza A virus type I only, and its therapeutic effect was not obvious. The median inhibitory concentration (MTT) was 5.89 μg / mL and the corresponding therapeutic index was 3.28. The half inhibitory concentration against viral direct inhibition was 9.56 μg / mL and the corresponding therapeutic index was 2.02. Conclusion: Bingxian powder can prevent and direct inhibit the influenza A virus FM1 in vitro.