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Two kinds of methods for determining seismic parameters are presented, that is, the potential seismic source zoning method and grid-spatially smoothing method. The Gaussian smoothing method and the modified Gaussian smoothing method are described in detail, and a comprehensive analysis of the advantages and disadvantages of these methods is made. Then, we take centrai China as the study region, and use the Gaussian smoothing method and potential seismic source zoning method to build seismic models to calculate the mean annual seismic rate. Seismic hazard is calculated using the probabilistic seismic hazard analysis method to construct the ground motion acceleration zoning maps. The differences between the maps and these models are discussed and the causes are investigated. The results show that the spatial smoothing method is suitable for estimating the seismic hazard over the moderate and low seismicity regions or the hazard caused by background seismicity; while the potential seismic source zoning method is suitable for estimating the seismic hazard in well-defined seismotectonics. Combining the spatial smoothing method and the potential seismic source zoning method with an integrated account of the seismicity and known seismotectonics is a feasible approach to estimate the seismic hazard in moderate and low seismicity regions.