论文部分内容阅读
[目的]分析体部伽玛刀联合化疗治疗局部晚期非小细胞肺癌(NSCLC)的疗效。[方法]自2002年1月至2004年1月收治晚期NSCLC157例。随机分为两组:单纯伽玛刀治疗组92例,伽玛刀联合化疗组65例。体部伽玛刀治疗:55%～70%等剂量线,3.0Gy～4.5Gy/次,治疗次数8～13次,总剂量40Gy～49.5Gy。化疗:采用NP方案,于伽玛刀治疗后1周左右开始,共3个周期。[结果]单纯伽玛刀治疗组有效率为81.5%,伽玛刀联合化疗组有效率为86.2%,两组比较差异无显著。单纯伽玛刀治疗组和伽玛刀联合化疗组的1年生存率分别为44.6%、49.2%;3年生存率分别为21.7%、27.7%。随访期内未见严重放射性并发症。[结论]伽玛刀联合化疗对局部晚期NSCLC有效,毒副作用轻微。
[Objective] To analyze the curative effect of body gamma knife combined with chemotherapy on locally advanced non-small cell lung cancer (NSCLC). [Methods] From January 2002 to January 2004, 157 cases of advanced NSCLC were treated. Randomly divided into two groups: simple gamma knife treatment group 92 cases, gamma knife combined chemotherapy group 65 cases. Body gamma knife treatment: 55% to 70% isodose line, 3.0Gy ~ 4.5Gy / times, the treatment of 8 to 13 times the total dose of 40Gy ~ 49.5Gy. Chemotherapy: The NP program, in the gamma knife treatment after about 1 week, a total of 3 cycles. [Result] The effective rate was 81.5% in the simple gamma knife group and 86.2% in the gamma knife combined with chemotherapy group. There was no significant difference between the two groups. The 1-year survival rates of simple gamma knife and gamma knife combined with chemotherapy were 44.6% and 49.2%, respectively. The 3-year survival rates were 21.7% and 27.7%, respectively. No serious radioactive complications were observed during the follow-up period. [Conclusion] Gamma Knife combined with chemotherapy is effective for locally advanced NSCLC with mild toxic and side effects.