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目的:研究胰岛素抵抗(IR)与高血压合并腔隙性脑梗塞患者之间的关系。方法:选取28例高血压合并腔隙性脑梗塞患者作为研究对象,测定血糖(FPG)、胰岛素水平(FINS)、C-肽、总胆固醇(CH)、甘油三脂(TG)。另28例正常健康老年人作为对照组,同时采用李光伟等提出的胰岛素敏感指效(ISI)方法进行IR计算。结果:高血压合并腔隙性脑梗塞患者FINS、C-肽水平显著高于对照组(p<0.01),其ISI较对照组显著降低(P<0.01)、脑梗死组FINS显著高于正常对照组(P<0.05),其ISI较正常对照组显著降低(p<0.05)。结论:老年高血压合并腔隙性脑梗塞患者存在IR,IR作为腔隙性脑梗塞独立危险因素应引起高度重视。
Objective: To study the relationship between insulin resistance (IR) and hypertension complicated with lacunar infarction. Methods: Twenty-eight patients with hypertension and lacunar infarction were enrolled in this study. Blood glucose (FPG), insulin (FINS), C-peptide, total cholesterol (CH) and triglyceride (TG) were measured. Another 28 normal healthy elderly as a control group, while using LI Guang-wei and other insulin sensitivity index (ISI) method for IR calculations. Results: The levels of FINS and C-peptide in hypertensive patients with lacunar infarction were significantly higher than those in the control group (p <0.01), and the ISI was significantly lower than that in the control group (P <0.01). The FINS in the cerebral infarction group was significantly higher than that in the normal control Group (P <0.05), the ISI was significantly lower than the normal control group (p <0.05). Conclusion: There are IR and IR as independent risk factors for lacunar infarction in elderly patients with hypertension and lacunar infarction.