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应用放射姓免疫分析技术观察ｒｈＥＤＩＬ－８对大鼠晚期失血性休克血浆６－ｋｅｔｏ－ＰＧＦ_（１α）和ＴＸＢ_２含量的影响，并与ＭＡＢＰ的变化作相关性分析。结果发现晚期失血性休克血浆６－ｋｅｔｏ－ＰＧＦ_（１α）含量明显降低（Ｐ＜０．０１），ＴＸＢ_２含量明显升高（Ｐ＜０．０１）；给予ｒｈＥＤＩＬ－８（２５０μｇ／ｋｇ）静脉注射后血浆６～ｋｅｔｏ－ＰＧＦ_（１α）含量明显升高，其血浆水平与ＭＡＢＰ呈明显的正相关性（ｒ＝０．７４６）；ｒｈＥＤＩＬ－８对血浆ＴＸＢ_２含量却无明显影响。研究结果提示：ｒｈＥＤＩＬ－８抗晚期失血性休克作用与其促进血管内皮细胞产生和释放ＰＧＩ_２有关。
The effect of rhEDIL-8 on the levels of 6-keto-PGF_ (1α) and TXB_2 in rats with hemorrhagic shock was observed by radioimmunoassay. Correlation analysis was performed with the changes of MABP. The results showed that the content of 6-keto-PGF1α in hemorrhagic shock group was significantly lower (P <0.01) and the content of TXB_2 was significantly higher (P <0.01), and rhEDIL-8 The plasma 6-keto-PGF_ (1α) level was significantly increased, and the plasma level was positively correlated with MABP (r = 0.746). However, rhEDIL-8 had no significant effect on plasma TXB_2 level. The results suggest that the anti-late hemorrhagic shock effect of rhEDIL-8 is related to its effect on the production of vascular endothelial cells and the release of PGI_2.