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目的探讨宫颈癌患者的梅毒感染情况和血液学相关指标的特征分析。方法将2014年9月-2016年10月在该院就诊的宫颈癌及癌前病变患者116例分为宫颈癌组和癌前病变组,每组各58例;另选取同期在该院体检的健康女性75例作为对照组。采用梅毒螺旋体明胶颗粒凝集试验检测3组患者的梅毒感染情况,并检测血液中常规指标中性粒细胞/淋巴细胞比率(NLR)、纤维蛋白原(FIB)、单核细胞、血红蛋白(Hb)及血清白蛋白(ALB)。结果宫颈癌组梅毒感染例数为13例(22.41%),癌前病变组梅毒感染例数为5例(8.62%),两组相比,差异有统计学意义(P<0.05);对照组梅毒感染例数为1例(1.33%),与癌前病变组相比,差异有统计学意义(P<0.05);与癌前病变组相比,宫颈癌组的NLR和FIB均显著上升(均P<0.05);与对照组相比,癌前病变组的NLR和FIB均显著上升(均P<0.05);与癌前病变组相比,宫颈癌组的单核细胞和Hb均显著减少(均P<0.05);与对照组相比,癌前病变组的单核细胞和Hb均显著减少(均P<0.05)。结论宫颈癌患者梅毒感染率较高,同时伴有炎症反应、血液高凝、免疫力低下、营养失衡等现象,因此应密切关注梅毒抗体及血常规的变化。
Objective To investigate the characteristics of syphilis infection and hematology-related indicators in patients with cervical cancer. Methods 116 patients with cervical cancer and precancerous lesions treated in this hospital from September 2014 to October 2016 were divided into cervical cancer group and precancerous lesions group, 58 cases in each group. In the same period, 75 healthy women as a control group. Treponema pallidum gelatin particle agglutination test was used to detect the syphilis infection in three groups of patients and the blood routine indexes of neutrophil / lymphocyte ratio (NLR), fibrinogen (FIB), monocytes, hemoglobin (Hb) and Serum albumin (ALB). Results There were 13 cases (22.41%) of syphilis infection in cervical cancer group and 5 cases (8.62%) of syphilis infection in precancerous lesions group, the difference was statistically significant (P <0.05) The number of cases of syphilis infection was 1 case (1.33%), which was significantly different from that of precancerous lesions group (P <0.05). Compared with precancerous lesions group, the NLR and FIB of cervical cancer group increased significantly (All P <0.05). Compared with the control group, the NLR and FIB in precancerous lesions were significantly increased (all P <0.05). Compared with precancerous lesions, the number of monocytes and Hb in cervical cancer significantly decreased (All P <0.05). Compared with the control group, monocytes and Hb in precancerous lesions were significantly decreased (all P <0.05). Conclusions Cervical cancer patients have a high syphilis infection rate, accompanied by inflammatory reaction, hypercoagulability, low immunity and imbalanced nutrition. Therefore, close attention should be paid to the changes of syphilis antibody and blood routine.