目的探讨淀粉样变的胃镜、肠镜表现特点以及粘膜活组织检查对其诊断的价值。方法分析内镜诊断的10例淀粉样变患者资料(男5例,女5例),分别总结胃镜、肠镜表现及其活组织检查特点。结果胃肠道淀粉样变患者的临床症状包括腹痛、便血或黑便、腹胀、慢性腹泻。5例接受胃镜检查的患者中,3例发现淀粉样变,阳性病变包括溃疡、结节、粘膜剥脱、瘢痕,还有1例患者在外观正常处取材确诊。8例接受肠镜检查的患者中,均发现淀粉样变,阳性病变包括息肉、溃疡、粘膜剥脱、结节不平及粘膜充血、水肿等。结论胃肠道是淀粉样变的好发部位之一,内镜检查可发现病变,其粘膜活组织检查具有重要的诊断价值。 Objective To investigate the characteristics of amyloid endoscopy, colonoscopy and mucosal biopsy for its diagnostic value. Methods The data of 10 patients with amyloidosis diagnosed by endoscopy (5 males and 5 females) were analyzed. The features of gastroscopy, colonoscopy and biopsy were summarized respectively. Results The clinical symptoms of gastrointestinal amyloidosis include abdominal pain, blood in the stool or melena, bloating and chronic diarrhea. Of the 5 patients who underwent endoscopy, 3 had amyloidosis, including ulceration, nodules, mucosal exfoliation, and scarring, and one patient was diagnosed as having normal appearance. All 8 patients who underwent colonoscopy were found to have amyloidosis. Positive lesions included polyps, ulcers, mucosal exfoliation, uneven nodules and mucosal congestion and edema. Conclusion The gastrointestinal tract is one of the most common sites of amyloidosis. Endoscopic examination can detect lesions and the mucosal biopsy has important diagnostic value.