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目的:探讨分析结缔组织病合并多器官损害患者D-二聚体(DD)、血流变学指标(血浆纤维蛋白原/血浆纤维蛋白降解产物FDP、全血黏度、血浆黏度)水平及指标变化对结缔组织病合并多器官损害患者病情活动期的诊疗价值。方法:本研究共纳入120例患者,其中活动组患者60例,病情缓解组患者60例,分别测定二组患者DD、血流变学指标水平,并采用t检验、灵敏度与特异度进行统计学分析与描述。结果:与缓解组比较,活动组DD、纤维蛋白降解产物(FDP)、全血黏度、血浆黏度、γ球蛋白、补体C4、ESR均具有统计学差异(P<0.01),补体C3组间差异也具有统计学意义(P<0.05)。各指标对于疾病活动性诊断的准确性,其DD>FDP>补体C3、C4>γ-球蛋白>血浆黏度>全血黏度>ESR。结论:结缔组织病合并多器官损害患者,其纤溶水平、微循环状态与疾病活动密切相关。
Objective: To investigate the changes of D-dimer (DD), hemorrheological indexes (plasma fibrinogen / FDP, whole blood viscosity and plasma viscosity) in patients with connective tissue disease and multiple organ damage Diagnosis and treatment of patients with connective tissue disease and multiple organ damage during the active stage of the disease. Methods: A total of 120 patients were enrolled in this study, including 60 patients in active group and 60 patients in remission group. The levels of DD and hemorheology in the two groups were measured. The t-test, sensitivity and specificity were used for statistics Analysis and description. Results: Compared with the relief group, DD, FDP, whole blood viscosity, plasma viscosity, gamma globulin, complement C4 and ESR in the active group were significantly different (P <0.01) Also statistically significant (P <0.05). Each index for the diagnosis of disease activity accuracy, its DD> FDP> complement C3, C4> γ-globulin> plasma viscosity> whole blood viscosity> ESR. Conclusion: The patients with connective tissue disease complicated with multiple organ damage have a close relationship between fibrinolytic level and microcirculation status and disease activity.