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目的探讨Livin mRNA在喉癌中的表达及意义。方法采用RT-PCR(逆转录-聚合酶链反应)方法检测41例喉癌及癌旁组织、12例声带息肉新鲜标本中Livin mRNA的表达。结果在喉癌组织标本中可检测到Livin mRNA的高表达,而在癌旁组织及声带息肉中呈低量表达,有显著性差异(P<0.01)。结论 Livin基因的表达水平上调与喉癌的发生密切相关,可能在喉癌的发生、发展中起重要作用。
Objective To investigate the expression of Livin mRNA in laryngeal carcinoma and its significance. Methods The expression of Livin mRNA in fresh specimens of 41 cases of laryngeal carcinoma and adjacent tissues and 12 cases of vocal cord polyps was detected by reverse transcription-polymerase chain reaction (RT-PCR). Results The high expression of Livin mRNA was detected in the specimens of laryngeal cancer, while the expression of Livin mRNA was low in adjacent tissues and vocal cord polyp. There was a significant difference (P <0.01). Conclusion The up-regulation of Livin gene expression is closely related to the occurrence of laryngeal carcinoma and may play an important role in the occurrence and development of laryngeal carcinoma.