观察分别接种地鼠巢细胞（ＣＨＯ）和酵母菌表达的乙型肝炎病毒表面抗原基因工程疫苗的母亲ＨＢｓＡｇ和ＨＢｅＡｇ同时阳性新生儿２０例和１２０例。于３月龄时检出婴儿ＨＢｓＡｇ阳性２０例，随访至２４个月，１６例ＨＢｓＡｇ持续阳性成为ＨＢｓＡｇ慢性携带者，保护率８８１５％。抗ＨＢｓ阳性率和抗ＨＢｓ滴度均于婴儿９～１２月龄时达一高峰（１００％，１１２２８）。酵母菌表达的乙肝基因疫苗预防保护率和抗ＨＢｓ阳性率与ＣＨＯ苗无显著性差异。两种疫苗均具有较好的免疫源性和近保护效果。 To observe the positive HBsAg and HBeAg positive mothers of 20 mothers and 120 esophageal mothers who were inoculated with gentamicin (CHO) and yeast-expressed hepatitis B virus surface antigen genetically engineered vaccine respectively. Twenty HBsAg positive cases were detected at 3 months of age and were followed up to 24 months. Sixteen cases of persistent HBsAg positive HBsAg carriers were chronic carriers with a protection rate of 88.15%. The positive rate of anti-HBs and anti-HBs titer reached a peak at 9-12 months of age (100%, 11228). Yeast expression of hepatitis B gene vaccine prevention and protection of anti-HBs positive rate and CHO seedlings no significant difference. Both vaccines have good immunogenicity and close protection.