论文部分内容阅读
A meta- analysis of pooled individual patient data from four randomized, placebo- controlled, double- blind trials comparing several doses of almotriptan (n = 1908) with placebo (n = 386) was used to investigate the efficacy, speed of onset and tolerability of almotriptan in the acute treatment of migraine. As early as 30 min after dosing, almotriptan 12.5 mg was significantly more effective than placebo for pain relief (14.9% vs. 8.2% ; P < 0.05) and pain free (2.5% vs. 0.7% ; P < 0.05). At 2 h, pain- relief rates were 56.0% , 63.7% and 66.0% for almotriptan 6.25, 12.5 and 25 mg, respectively, compared with 35% for placebo; 2- h pain- free rates were 26.7% , 36.4% and 43.4% compared with 13.9% for placebo. All almotriptan dosages were significantly more effective than placebo in eliminating migraine- associated symptoms (P < 0.05) and in achieving sustainedpain relief up to 24 h(P < 0.05). The incidence of adverse events after almotriptan 6.25 mg and 12.5 mg was not significantly different from that of placebo. This meta- analysis confirms the findings of individual clinical trials, while demonstrating for the first time, significant pain- free efficacy at 30 min compared with placebo.
A meta-analysis of pooled individual patient data from four randomized, placebo-controlled, double-blind trials comparing several doses of almotriptan (n = 1908) with placebo (n = 386) was used to investigate the efficacy, speed of onset and tolerability of almotriptan in the acute treatment of migraine. As early as 30 min after dosing, almotriptan 12.5 mg was significantly more effective than placebo for pain relief (14.9% vs. 8.2%; P <0.05) and pain free (2.5% vs. 0.7 %; P <0.05). At 2 h, pain-free rates were 56.0%, 63.7% and 66.0% for almotriptan 6.25, 12.5 and 25 mg, respectively, compared with 35% for placebo; 2- h pain- free rates were All almotriptan dosages were significantly more effective than placebo in eliminating migraine-associated symptoms (P <0.05) and sustained growth of up to 24 h (P <0.05). The incidence of adverse events after almotriptan 6.25 mg and 12.5 mg was not significantly diff This meta-analysis confirms the findings of individual clinical trials, while demonstrating for the first time, significant pain-free efficacy at 30 min compared with placebo.