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目的:探讨死亡诱导蛋白(DIP)在肝细胞癌(HCC)中的表达及其与肝癌临床病理特征之间的关系。方法:运用RT-PCR免疫组化分别检测DIP在40例HCC及其癌旁组织中的表达情况,并分析DIP蛋白表达与HCC临床病理特征之间的相关性;应用RT-PCR检测人正常肝细胞株LO2和HCC细胞Hep3B,HepG2,SMMC-7721中DIP mRNA的表达。结果:DIP mRNA及蛋白在肝癌组织中的表达明显高于其癌旁组织(均P<0.05);DIP蛋白高表达与较大肿瘤体积、高Edmonson分级和高TNM分期有关(r=0.419,0.414,0.531;均P<0.05);人HCC细胞株Hep3B,HepG2,SMMC-7721中DIP mRNA的表达均较正常肝细胞株LO2明显增高(均P<0.05)。结论:HCC组织中DIP表达上调,且这种表达上调与HCC的恶性病理特征相关。
Objective: To investigate the expression of death-inducing protein (DIP) in hepatocellular carcinoma (HCC) and its relationship with clinicopathological features of hepatocellular carcinoma. Methods: The expression of DIP in 40 cases of HCC and adjacent normal tissues was detected by RT-PCR, and the correlation between DIP protein and clinicopathological features was analyzed. RT-PCR was used to detect the expression of human normal liver Cell line LO2 and HCC Hep3B, HepG2, SMMC-7721 DIP mRNA expression. Results: The expression of DIP mRNA and protein in HCC tissues was significantly higher than that in adjacent non-cancerous tissues (P <0.05). The high expression of DIP protein was associated with larger tumor volume, higher Edmonson grade and higher TNM stage (r = 0.419,0.414 , 0.531, all P <0.05). The mRNA expression of DIP in Hep3B, HepG2 and SMMC-7721 cells was significantly higher than that in normal hepatocytes (all P <0.05). Conclusion: The expression of DIP in HCC tissue is up-regulated, and the upregulation of this expression is associated with the malignant pathological features of HCC.