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应用免疫组化染色技术,研究了TLSF_(JM)对T细胞IL-2R表达和蛋白酪氨酸磷酸化的调节作用。结果表明:TLSF_(JM)对PHA或PA活化的人PBMC以及小鼠CTLL-2 IL-2R表达和蛋白酪氨酸磷酸化具有明显的抑制作用,但对在T淋巴细胞增殖、分化过程中起重要作用的细胞因子IL-1、IL-2和IL-6的产生无明显影响。
Immunohistochemical staining was used to study the regulatory effect of TLSF_ (JM) on IL-2R expression and tyrosine phosphorylation in T cells. The results showed that TLSF_ (JM) significantly inhibited the expression of CTL-2 IL-2R and protein tyrosine phosphorylation in human PBMCs activated by PHA or PA, but played an important role in the proliferation and differentiation of T lymphocytes The production of IL-1, IL-2 and IL-6, the important cytokines, had no significant effect.