目的:探讨24h尿蛋白与妊高征围产期结局的关系。方法:于2007年6月～2008年8月间收集85例妊高征孕妇及55例正常晚期妊娠孕妇的尿液和血液,采用全自动生化分析仪检测24h尿蛋白和血清白蛋白水平。结果:妊高征组与正常妊娠组在分娩周数、血清白蛋白、24h尿蛋白量、剖宫产、低体重儿、早产儿、新生儿体重上比较,有明显统计学差异(P<0.01),两组新生儿窒息率和围生儿死亡率差异有统计学意义(P<0.05),而且随着24h尿蛋白含量的增加,新生儿体重逐渐减低。结论:妊高征患者尿蛋白的水平与病情程度和围产儿预后密切相关。应严格监测24h尿蛋白量,为妊高征的诊断、治疗和母婴预后提供依据。 Objective: To investigate the relationship between 24h urine protein and perinatal outcome of pregnancy induced hypertension. Methods: Urine and blood of 85 pregnant women with PIH and 55 normal pregnant women of late pregnancy were collected from June 2007 to August 2008. Urine protein and serum albumin were detected by automatic biochemical analyzer. Results: Compared with the normal pregnancy group, there were significant differences in the number of weeks of delivery, serum albumin, 24-hour urine protein, cesarean section, low birth weight, premature infant and newborn weight (P <0.01) ). There was significant difference in neonatal asphyxia and perinatal mortality between the two groups (P <0.05). And with the increase of urinary protein in 24 hours, the weight of neonates decreased gradually. Conclusion: The level of urinary protein in patients with PIH is closely related to the degree of illness and the prognosis of perinatal children. Should be strictly monitored 24-hour urinary protein levels for the diagnosis and treatment of pregnancy-induced hypertension and maternal and child prognosis provide the basis.