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本文用ＵＶ法测定健康成人口服吲哚美辛锌、吲哚美辛胶囊剂后的尿药浓度，以酸－碱法提取尿中吲哚美辛原形药，在２６５ｎｍ处测定吸收度，在４～３２ｕｇ／ｍｌ范围内线性关系良好，平均回收率＞９９．０％，日内及日间ＲＳＤ＜０．９２％，对６名健康志愿者口服给药后的药物动力学研究结果：吲哚美辛锌及吲哚美辛的药动学参数分别为，Ｔｍａｘ＝３．３２，１．８７（Ｐ＜０．０１）；Ｋ＝０．１２７３，０．１５３１（Ｐ＜０．０５）；Ｔ１／２＝５．４７，４．６１（ｐ＜０．０５）；Ｘｕ（ｍｇ）＝１０．９１，１３．１４（Ｐ＞０．０５）吲哚美锌的相对生物利用度为８３．０３％。
In this paper, UV determination of healthy adults oral indomethacin zinc, indomethacin capsules after the urine concentration of acid-base extraction of indomethacin in urine urine samples measured absorbance at 265nm, at 4 ~ 32 ug / ml within a good linear relationship, the average recovery was> 99.0%, intra-day and day RSD <0.92%, pharmacokinetic study of six healthy volunteers after oral administration: Indomethacin The pharmacokinetic parameters of octylzinc and indomethacin were Tmax = 3.32,1.87 (P <0.01); K = 0.1273,0.1531 (P <0.05); T1 /2=5.47,4.61(p<0.05);Xu(mg)=10.91,13.14(P>0.05) The relative bioavailability of indomethazine was 83.03 %.