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目的：比较培氟沙星与头孢曲松对细菌感染的疗效。方法：用培氟沙星注射液治疗细菌感染５０例（男性２６例，女性２４例；年龄５８±ｓ１３ａ），剂量４００～８００ｍｇ／次，加入５％葡萄糖液１００ｍＬ中静脉滴注，每日２次。另用头孢曲松２ｇ加５％葡萄糖液２５０ｍＬ中静脉滴注，每日１次，治疗５０例作对照。２组用药天数均为９±３ｄ（４～１８ｄ）。结果：培氟沙星组临床有效率为８２％，细菌阴转率为８０％，对照组分别为７８％和７５％。２组无明显差异（Ｐ＞０．０５），且均未发现有严重不良反应。结论：培氟沙星与头孢曲松治疗细菌性感染疗效无差别，是一种抗菌作用强、对临床难治和严重的感染有满意疗效的抗菌药物。
OBJECTIVE: To compare the efficacy of pefloxacin and ceftriaxone against bacterial infections. Methods: Pefloxacin injection was used to treat 50 bacterial infections (26 males and 24 females; age 58 ± s13a) at a dosage of 400-800 mg / Times. Another ceftriaxone 2g plus 5% glucose solution 250mL intravenous infusion, once a day, 50 cases of treatment as a control. The days of medication in both groups were 9 ± 3d (4 ~ 18 days). Results: The pefloxacin group had a clinical effective rate of 82%, a bacterial negative conversion rate of 80% and a control group of 78% and 75% respectively. No significant difference between the two groups (P> 0.05), and no serious adverse reactions were found. Conclusion: Pefloxacin and ceftriaxone treatment of bacterial infections no difference in efficacy, is a strong antibacterial effect of clinical refractory and severe infections with satisfactory curative effect of antibacterial drugs.