目的:研究早期肠内营养添加谷氨酰胺对昏迷儿童营养和免疫功能的影响。方法:将符合入选条件的昏迷儿童根据肠内营养分为添加谷氨酰胺组(GEN组)和未添加谷氨酰胺组(EEN组),比较2组患儿治疗前、治疗后体质量指数、PA、ALB、TP、IgG、IgA、IgM、CD3~+、CD4~+和CD8~+的差异。结果:GEN组和EEN组昏迷患儿治疗前体质量指数、PA、ALB、TP、IgG、IgA、IgM、CD3~+、CD4~+和CD8~+均无明显差异,EEN组昏迷患儿治疗后的体质量指数、PA、ALB、TP、IgG、IgA、IgM、CD3~+、CD4~+和CD8~+较治疗前无明显改变;GEN组昏迷患儿治疗后的PA、ALB、TP、IgG、IgA、IgM、CD3~+、CD4~+和CD8~+较治疗前均显著增加(均P<0.05),且均显著高于EEN组昏迷患儿(均P<0.05)。结论:早期肠内营养添加谷氨酰胺可显著提高昏迷儿童营养状况及免疫功能,其疗效显著高于单纯肠内营养。 Objective: To study the effects of early enteral nutrition supplementation of glutamine on nutrition and immune function in coma children. Methods: The comatose children who met the inclusion criteria were divided into two groups according to enteral nutrition: adding glutamine group and no glutamine group (EEN group). Before and after treatment, body mass index, PA, ALB, TP, IgG, IgA, IgM, CD3 ~ +, CD4 ~ + and CD8 ~ +. Results: There were no significant differences in body mass index, PA, ALB, TP, IgG, IgA, IgM, CD3 +, CD4 + and CD8 + in coma children in GEN group and EEN group The body mass index, PA, ALB, TP, IgG, IgA, IgM, CD3 +, CD4 + and CD8 + had no significant change before treatment. The levels of IgG, IgA, IgM, CD3 +, CD4 + and CD8 + increased significantly (all P <0.05) compared with before treatment, and were significantly higher than those in EEN coma (all P <0.05). Conclusion: Adding glutamine to early enteral nutrition can significantly improve the nutritional status and immune function of coma children, and its efficacy is significantly higher than that of simple enteral nutrition.