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目的探讨大剂量纳洛酮对脑出血患者神经功能的保护作用效果。方法连续纳入80例脑出血患者并随机分为观察组和对照组,观察组采用大剂量纳洛酮,对照组采用小剂量纳洛酮,比较两组患者治疗前后神经功能缺损评分及生活质量。结果治疗前两组患者神经功能损伤无明显差异(P>0.05),治疗后观察组降至(15.57±4.42),而对照组为(23.24±5.18),观察组神经功能损伤预后好于对照组(P<0.05)。生活质量评分:观察组治疗前为(32.34±7.95),治疗后为(62.34±6.78),对照组治疗前为(31.11±7.82),治疗后为(43.57±7.42),观察组患者比对照组患者生活质量提高更多(P<0.05)。结论大剂量纳洛酮能有效保护脑出血患者神经功能,提高生活质量,临床效果显著。
Objective To investigate the protective effects of high-dose naloxone on neurological function in patients with intracerebral hemorrhage. Methods Eighty consecutive patients with cerebral hemorrhage were enrolled and randomly divided into observation group and control group. The observation group was given high-dose naloxone and the control group was given low-dose naloxone. The neurological deficit scores and quality of life were compared between the two groups before and after treatment. Results There was no significant difference in neurological impairment between the two groups before treatment (P> 0.05). After treatment, the observation group was reduced to (15.57 ± 4.42), while the control group was (23.24 ± 5.18). The prognosis of neurological impairment in the observation group was better than that in the control group (P <0.05). The quality of life of the observation group was (32.34 ± 7.95) before treatment, (62.34 ± 6.78) after treatment, (31.11 ± 7.82) before treatment and (43.57 ± 7.42) after treatment, while the observation group than the control group Patients’ quality of life improved more (P <0.05). Conclusion High-dose naloxone can effectively protect the neurological function of patients with cerebral hemorrhage and improve the quality of life. The clinical effect is remarkable.