目的：探讨普罗布考联合水化对冠状动脉介入治疗术后肾功能的影响及作用机制。方法前瞻性连续入选在天津市胸科医院心内科行冠状动脉介入治疗（PCI）术的患者共240例，随机分为普罗布考组（120例）和对照组（120例），普罗布考组给予普罗布考联合水化治疗，对照组仅给予水化治疗。观察两组患者PCI术前及术后肾功能、C-反应蛋白（CRP）、白细胞介素-6（IL-6）以及丙二醛（MDA）的变化，同时记录两组患者急性肾损伤（CIN）发生情况。 CIN：PCI术后72h内Scr水平较原有基础升高>25%或者绝对值升高>44.2μmol/L。结果普罗布考组CIN发生率为2.5%，对照组CIN发生率为9.2%，两组发生率差异有统计学意义（χ2=4.79，P0.05），两组术后72h血Scr、CRP、IL-6、MDA均较术前增高；术后72h，普罗布考组CRP、IL-6、MDA水平低于对照组，Ccr高于对照组（P<0.05）。结论普罗布考联合水化可降低PCI术后CIN的发生率，其可能的作用机制是普罗布考的抗氧化应激及抗炎症作用。“,”Objective To investigate the preventive effect of probucol on contrast induced nephropathy(CIN) in patients undergoing percutaneous coronary intervention (PCI). Methods 240 patients underwent PCI in Tianjin Chest Hospital were randomly divided into probucol group (n=120) and control group (n=120).Patients in the probucol group were given probucol combined with hydration. Control group was only treated with hydration. The levels of blood urea nitrogen (BUN), serum creati-nine (Scr), creatinine clear rate (Ccr), interleukin-6 (IL-6), C-reactive protein (CRP), Malondialdehyde (MDA) were mea-sured at admission and 72h after the procedure. Results In the probucol group, only 3 patients present with CIN,the inci-dence of CIN was 2.5%. In the control group, CIN occured in 11 patients, the incidence of CIN was 9.2%(χ2=4.79,P0.05). 72h after the procedure, the levels of CRP,IL-6,MDA were lower in probucol group than the control group (P<0.05), and the level of Ccr was higher in the probucol group than the control group(P<0.05). Conclusion Probucol before PCI may be ben-eficial in the prevention of CIN. The protection mechanism may be due to the anti-inflammation and antioxidant sress effects.