本研究应用DMBA(二甲基苯丙蒽)丙酮涂抹64只叙利亚金黄地鼠双侧颊囊,建立口腔癌前病变动物模型,分阻断组和对照组,局部粘膜下注射0.8％硫代脯氨酸的动物40％的病变逆转趋向于正常组织,而对照组100％的病变发生癌变。结果表明,硫代脯氨酸可能通过某种调控机制,改变结缔组织性质,改善微循环,诱导上皮的正常分化,从而发挥对口腔癌病的阻断作用。 In this study, bilateral buccal pouches of 64 Syrian hamsters were applied with DMBA (acetone) to establish an animal model of oral precancerous lesions. The animals were divided into two groups: the blocking group and the control group, and the submucosal injection of 0.8% Forty percent of the animals in the amino acid group tended to turn normal, whereas 100% of the control group developed canceration. The results showed that thioproline may exert its blocking effect on oral cancer by some regulatory mechanism, changing the properties of connective tissue, improving microcirculation and inducing the normal differentiation of epithelial cells.