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目的:探讨奥格扎格雷钠联合低分子肝素钙对急性血栓性脑梗死患者脑血流及神经功能状态的影响。方法:选自2014年2月-2015年4月期间东阳市人民医院收治的188例急性血栓性脑梗死患者按照随机分组法分为观察组(n=94)与对照组(n=94)。两组均采用常规对症治疗。对照组采用低分子肝素钙治疗,观察组在低分子肝素钙基础上结合奥格扎格雷治疗。两组疗程均为14d。对比分析两组治疗疗效,治疗前后神经功能缺损评分(NIS)、日常生活能力(ADL)评分及脑血流指标水平变化,及药物副作用发生情况。结果:观察组总有效率(86.17%)高于对照组(70.21%)(P<0.05);两组NIS评分对比治疗后低于治疗前(P<0.05),ADL评分对比治疗后高于治疗前(P<0.05);观察组NIS评分对比治疗后低于对照组(P<0.05),ADL评分对比治疗后高于对照组(P<0.05);两组Vm、PSV、PI对比治疗后高于治疗前(P<0.05),而RI对比治疗后低于治疗前(P<0.05);观察组Vm、PSV、PI对比治疗后高于对照组(P<0.05),而RI对比治疗后低于对照组(P<0.05);两组均未见严重药物副作用。结论:奥格扎格雷钠联合低分子肝素钙可改善急性血栓性脑梗死患者脑血流状态,有利于神经功能恢复,疗效显著。
Objective: To investigate the effects of ozogrel and sodium low molecular weight heparin on cerebral blood flow and neurological status in patients with acute thrombotic cerebral infarction. Methods: A total of 188 acute thrombotic cerebral infarction patients from Dongyang People’s Hospital from February 2014 to April 2015 were randomly divided into observation group (n = 94) and control group (n = 94). Both groups were treated with conventional symptomatic treatment. The control group treated with low molecular weight heparin, the observation group combined with low molecular weight heparin calcium combined with OG Zagre treatment. Two groups of treatment are 14d. The curative effect, nerve function impairment score (NIS), ADL score and cerebral blood flow index level before and after treatment were compared between the two groups, and the occurrence of drug side effects. Results: The total effective rate (86.17%) in the observation group was higher than that in the control group (70.21%) (P <0.05). The NIS scores of the two groups were lower than those before treatment (P <0.05) (P <0.05). NIS score of the observation group was lower than that of the control group (P <0.05), ADL score was higher than that of the control group after treatment (P <0.05) (P <0.05), while RI in the control group was lower than that in the control group before treatment (P <0.05). Vm, PSV and PI in the observation group were significantly higher than those in the control group (P <0.05) In the control group (P <0.05); no serious side effects were observed in both groups. Conclusion: Ogzagrel sodium combined with low molecular weight heparin can improve cerebral blood flow in patients with acute thrombotic cerebral infarction, which is good for neurological function recovery.