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ＡＦＢ１和ＨＢＶ是致肝癌的两个主要因素。研究表明ＡＦＢ１与ＨＢＶ有协同致肝癌作用，但其机理不明。方法利用ＨＢＶ转基因小鼠模型，分析小鼠肝脏组织中的细胞色素Ｐ４５０酶的含量和活性，ＧＳＨ和ＧＳＴ的含量和活性，并测定ＨＢＶ转基因小鼠暴露于ＡＦＢ１后血清ＡＦＢ１┐白蛋白加成物的含量。结果加成物的含量在ＨＢＶ转基因小鼠都较对照小鼠高，细胞色素Ｐ４５０酶含量明显降低而活性有所上升，ＧＳＨ含量和ＧＳＴ酶活性都明显下降。结论ＨＢＶ转基因小鼠的解毒代谢能力下降。ＨＢＶ影响了小鼠的解毒代谢，使小鼠对ＡＦＢ１敏感。
AFB1 and HBV are the two major contributors to HCC. Studies have shown that AFB1 and HBV have a synergistic effect on liver cancer, but its mechanism is unknown. Methods The HBV transgenic mice model was used to analyze the contents and activities of cytochrome P450 enzymes and the contents and activities of GSH and GST in the liver of mice and the changes of serum AFB1 ┐ albumin adducts after HBV transgenic mice were exposed to AFB1 Content. Results The content of adduct in HBV transgenic mice was higher than that in control mice. The content of cytochrome P450 enzyme decreased obviously while the activity increased, and the content of GSH and the activity of GST decreased significantly. Conclusion HBV transgenic mice have a decreased ability to detoxify and metabolize. HBV affects the detoxification metabolism of mice and makes mice sensitive to AFB1.